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Does Testosterone Replacement Therapy work? What is TRT?

Updated: Oct 31, 2022

Testosterone replacement therapy (TRT) is quite common in developed countries. For example, sales of testosterone drugs in the U.S. total $2 billion a year. This industry is growing every year. The reason for this is the growing popularity of TRT among men. Many studies are conducted every year on TRT, and confirm that Testosterone Replacement Therapy is safe for men's health if all the precautions are taken and the dosage is strictly followed.

The Purpose of Testosterone Replacement Therapy

As men age, testosterone levels decline. Testosterone replacement therapy provides an opportunity to avoid some negative health effects resulting from the lack of this essential hormone. Scientists have identified the potential benefits and risks of testosterone replacement therapy through numerous studies.

The volume of natural testosterone production in men decreases for various reasons. These include physical inactivity, genetic predisposition, hormone imbalance, or thyroid disease. However, when the concentration of this hormone is low, men can increase its production thanks to TRT (Testosterone Replacement Therapy).

Benefits of TRT:

  • Increased libido (sex drive and quality of sex life);

  • Increased stamina and muscle strength;

  • Growth of muscle strength;

  • Getting rid of gynecomastia in men;

  • Improvement of sleep and brain productivity;

  • Normalization of hormonal balance.

Numerous studies have shown that these effects are achieved with testosterone replacement therapy in men of all ages. Therefore, you may perform this therapy at 21 to 65 years old without any significant risks or deviations from standard health indicators.

This therapy is intended primarily for men between the ages of 30 and 65 who are experiencing problems with their sex life. A decrease in serum testosterone levels begins in men in their 30s. After that, hormone levels decrease by an average of 1.6% per year. However, due to genetic factors, the decrease may be accelerated, and the natural production of the hormone may be lower. Some authors describe the decline as a decrease in the quality of sexual life after 30; without erections, gynecomastia, and low-energy levels.

TRT (Testosterone Replacement Therapy) is also necessary for athletes participating in power sports. For example, bodybuilders or fitness athletes often use this therapy to increase their strength and muscle mass. Testosterone is the main hormone that contributes to natural strength, increased libido, sexual stamina, and muscle growth.

Methods Of Testosterone Replacement Therapy (TRT)

There are different methods of TRT that are used in modern pharmacology:

  • Gel (rubbed into the skin);

  • Injections;

  • Patch (glued to the skin);

  • Pellets are implanted under the skin.

These methods are safe for human health. The doctor chooses the method according to the patient's prescription, goals, and health status.


In modern medicine, the use of different methods of Testosterone Replacement Therapy is absolutely safe if the norms are followed. Before artificially increasing the testosterone level in the blood, a number of examinations should be carried out via blood testing. If the key health indicators are normal, it is safe to perform TRT. This therapy rarely causes side effects without preexisting heart disease, malignant tumors, and metabolic disorders. Therefore, testosterone Replacement Therapy is not recommended only for those with genetic abnormalities, heart disease, tumors, and other serious health conditions. Otherwise, TRT is an effective way to restore testosterone levels, restore sexual activity and increase stamina.


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